Adiabatic Spiral Correlation Chemical Shift Imaging

Introduction The overlap of spectra in magnetic resonance spectroscopy limits the unambiguous identification and quantification of metabolites. Two of the most employed approaches involve fitting with a known basis set [1] and spectral editing [2]. Alternatively, multidimensional correlation spectroscopy [3] does not need to assume a certain basis set, nor needs to filter-out metabolites as in spectral editing. Here we present novel pulses sequences for correlation chemical shift imaging (CCSI) that use adiabatic excitation and spiral encoding to acquire the four dimensional (kx,ky,t1,t2) space. Methods All experiments were demonstrated on whole-body 3T Tim Trio clinical scanners (Siemens, Erlangen, Germany), using body coil for transmit and the 32-channel head coil for receive. We designed new pulse sequences for multivoxel two-dimensional (2D) Correlation Spectroscopy (COSY) and Total Correlation Spectroscopy (TOCSY) shown in Figure 1.